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1

Adaptive designs in clinical trials: why use them, and how to run and report them

Pallmann, Philip, Bedding, Alun W., Choodari-Oskooei, Babak, Dimairo, Munyaradzi, Flight, Laura, Hampson, Lisa V., Holmes, Jane, Mander, Adrian P., Odondi, Lang’o, Sydes, Matthew R., Villar, Sofía S.,

Journal:

Year:

2018

Language:

english

File:

PDF, 887 KB

english, 2018

2

Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis

Adrian P. Mander, James M.S. Wason, Michael J. Sweeting, Simon G. Thompson

Journal:

Pharmaceutical Statistics

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

3

Dietary energy density and adiposity: Employing bias adjustments in a meta-analysis of prospective studies

Désirée C Wilks, Adrian P Mander, Susan A Jebb, Simon G Thompson, Stephen J Sharp, Rebecca M Turner, Anna Karin Lindroos

Journal:

BMC Public Health

Year:

2011

Language:

english

File:

PDF, 627 KB

english, 2011

4

Model selection and sample size adaptation: HYPAZ trial

Simon Bond, Adrian Mander, Duncan Jodrell, Joseph Cheryian

Journal:

Year:

2011

Language:

english

File:

PDF, 121 KB

english, 2011

5

Are devastating hurricanes becoming the norm?

Raine, Adrian, Andrews, Harry, Sheard, Charlotte, Walder, Christine, Manders, Duncan

Journal:

Year:

2007

Language:

english

File:

PDF, 101 KB

english, 2007

6

Weight loss referrals for adults in primary care (WRAP): protocol for a multi-centre randomised controlled trial comparing the clinical and cost-effectiveness of primary care referral to a commercial weight loss provider for 12

Amy L Ahern,Paul N Aveyard,Jason CG Halford,Adrian Mander…

Journal:

BMC Public Health

Year:

2014

Language:

english

File:

PDF, 379 KB

english, 2014

7

Correcting for multiple-testing in multi-arm trials: is it necessary and is it done?

Wason, James M S, Stecher, Lynne, Mander, Adrian P

Journal:

Year:

2014

Language:

english

File:

PDF, 689 KB

english, 2014

8

Group sequential crossover trial designs with strong control of the familywise error rate

Grayling, Michael J., Wason, James M. S., Mander, Adrian P.

Journal:

Sequential Analysis

Year:

2018

Language:

english

File:

PDF, 2.35 MB

english, 2018

9

Blinded and unblinded sample size reestimation procedures for stepped-wedge cluster randomized trials

Grayling, Michael J., Mander, Adrian P., Wason, James M. S.

Journal:

Biometrical Journal

Year:

2018

Language:

english

File:

PDF, 282 KB

english, 2018

10

Two-Stage Adaptive Designs for Three-Treatment Bioequivalence Studies

Grayling, Michael J., Mander, Adrian P., Wason, James M. S.

Journal:

Statistics in Biopharmaceutical Research

Year:

2019

File:

PDF, 2.50 MB

2019

11

Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD

Amanda J. Myers, Helen Marshall, Peter Holmans, Danielle Compton, Richard J.P. Crook, Adrian P. Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu, Jen C. Wang, Marian Hamshere, John C. Mo

Journal:

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

12

Parkinson's disease is not associated with the combined α-synuclein/apolipoprotein E susceptibility genotype

Naheed Khan, Elizabeth Graham, Peter Dixon, Christopher Morris, Adrian Mander, David Clayton, J. Vaughan, Niall Quinn, Andrew Lees, Susan Daniel, Nicholas Wood, Rohan De Silva

Journal:

Annals of Neurology

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

13

Multiple sclerosis recurrence risk for siblings in an isolated population of Central Sardinia, Italy

Cristina Montomoli, Inga Prokopenko, Antonella Caria, Raffaela Ferrai, Adrian Mander, Shaun Seaman, Luigina Musu, Maria L. Piras, Anna F. Ticca, Salvatore B. Murgia, Luisa Bernardinelli

Journal:

Genetic Epidemiology

Year:

2002

Language:

english

File:

PDF, 42 KB

english, 2002

14

Risk of ischaemic cardiovascular events from selective cyclooxygenase-2 inhibitors in osteoarthritis

Marianne Cunnington, David Webb, Nawab Qizilbash, David Blum, Adrian Mander, Michele Jonsson Funk, John Weil

Journal:

Pharmacoepidemiology and Drug Safety

Year:

2008

Language:

english

File:

PDF, 121 KB

english, 2008

15

An evaluation of Bayesian designs for dose-escalation studies in healthy volunteers

John Whitehead, Yinghui Zhou, Adrian Mander, Sally Ritchie, Antony Sabin, Andrew Wright

Journal:

Statistics in Medicine

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

16

Optimal multistage designs for randomised clinical trials with continuous outcomes

James M.S. Wason, Adrian P Mander, Simon G. Thompson

Journal:

Statistics in Medicine

Year:

2012

Language:

english

File:

PDF, 429 KB

english, 2012

17

Moderate Ingestion of Alcohol Is Associated With Acute Ethanol-Induced Suppression of Circulating CTX in a PTH-Independent Fashion

Supannee Sripanyakorn, Ravin Jugdaohsingh, Adrian Mander, Sarah L Davidson, Richard PH Thompson, Jonathan J Powell

Journal:

Journal of Bone and Mineral Research

Year:

2009

Language:

english

File:

PDF, 676 KB

english, 2009

18

Escalation strategies for combination therapy Phase I trials

Michael J. Sweeting, Adrian P. Mander

Journal:

Pharmaceutical Statistics

Year:

2012

Language:

english

File:

PDF, 519 KB

english, 2012

19

Restoring and managing natural capital towards fostering economic development: Evidence from the Drakensberg, South Africa

James Blignaut, Myles Mander, Roland Schulze, Mark Horan, Chris Dickens, Catherine Pringle, Khulile Mavundla, Isaiah Mahlangu, Adrian Wilson, Margaret McKenzie, Steve McKean

Journal:

Ecological Economics

Year:

2010

Language:

english

File:

PDF, 671 KB

english, 2010

20

Is sugar-sweetened beverage consumption associated with increased fatness in children?

Laura Johnson, Adrian P. Mander, Louise R. Jones, Pauline M. Emmett, Susan A. Jebb

Journal:

Year:

2007

Language:

english

File:

PDF, 298 KB

english, 2007

21

No difference in the 24-hour interstitial fluid glucose profile with modulations to the glycemic index of the diet

Louise M. Aston, Roberta Laccetti, Adrian P. Mander, Rosemary Hall, Carmel S. Moore, Susan A. Jebb

Journal:

Year:

2010

Language:

english

File:

PDF, 289 KB

english, 2010

22

23 Clinically relevant analyses of diary card data in asthma studies

Adrian Mander, Stephen Sharp, Carl Johan Lamm, Michael Hughes

Journal:

Controlled Clinical Trials

Year:

1997

Language:

english

File:

PDF, 79 KB

english, 1997

23

A phase 2 study of vatalanib in metastatic melanoma patients

Natalie Cook, Bristi Basu, Swethajit Biswas, Paula Kareclas, Colette Mann, Cheryl Palmer, Anne Thomas, Steve Nicholson, Bruno Morgan, David Lomas, Bhawna Sirohi, Adrian P. Mander, Mark Middleton, Pipp

Journal:

European Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 123 KB

english, 2010

24

Reducing sample sizes in two-stage phase II cancer trials by using continuous tumour shrinkage end-points

James M.S. Wason, Adrian P. Mander, Tim G. Eisen

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 397 KB

english, 2011

25

Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial

Susan A Jebb, Amy L Ahern, Ashley D Olson, Louise M Aston, Christina Holzapfel, Julia Stoll, Ulrike Amann-Gassner, Annie E Simpson, Nicholas R Fuller, Suzanne Pearson, Namson S Lau, Adrian P Mander, H

Journal:

Year:

2011

Language:

english

File:

PDF, 247 KB

english, 2011

26

Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Celia G. Walker, Ruth J. F. Loos, Adrian P. Mander, Susan A. Jebb, Gary S. Frost, Bruce A. Griffin, Julie A. Lovegrove, Thomas A. B. Sanders, Les J. Bluck

Journal:

Genes & Nutrition

Year:

2012

Language:

english

File:

PDF, 266 KB

english, 2012

27

Adaptive designs for dual-agent phase I dose-escalation studies

Harrington, Jennifer A., Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P., Jodrell, Duncan I.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2013

Language:

english

File:

PDF, 498 KB

english, 2013

28

Interhemispheric transfer in schizophrenics, depressives, and normals with schizoid tendencies

Raine, Adrian, Andrews, Harry, Sheard, Charlotte, Walder, Christine, Manders, Duncan

Journal:

Schizophrenia Research

Year:

1989

Language:

english

File:

PDF, 63 KB

english, 1989

29

SECTION OF ELECTRO-THERAPEUTICS.

Raine, Adrian, Andrews, Harry, Sheard, Charlotte, Walder, Christine, Manders, Duncan

Journal:

Year:

1915

Language:

english

File:

PDF, 638 KB

english, 1915

30

Adaptive enrichment in biomarker-stratified clinical trial design

Deepak Parashar,Jack Bowden,Colin Starr,Lorenz Wernisch,Adrian Mander

Journal:

Year:

2013

Language:

english

File:

PDF, 122 KB

english, 2013

31

Adaptive dose-finding designs to identify multiple doses that achieve multiple response targets

Simon Bond,Adrian Mander,John Todd,Linda Wicker,Frank Waldron-Lynch

Journal:

Year:

2013

Language:

english

File:

PDF, 121 KB

english, 2013

32

How to use published complete case results from weight loss studies in a missing data sensitivity analysis

Cresswell, Lynne, Mander, Adrian P.

Journal:

Year:

2014

Language:

english

File:

PDF, 310 KB

english, 2014

33

Genetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss

Walker, Celia G., Holzapfel, Christina, Loos, Ruth J.F., Mander, Adrian P., Klopp, Norman, Illig, Thomas, Caterson, Ian D., Hauner, Hans, Jebb, Susan A.

Journal:

Year:

2013

Language:

english

File:

PDF, 724 KB

english, 2013

34

Bayesian Hierarchical Methods to Interpret the 13C-Octanoic Acid Breath Test for Gastric Emptying

Bluck, Leslie J.C., Jackson, Sarah J., Vlasakakis, Georgios, Mander, Adrian

Journal:

Year:

2011

Language:

english

File:

PDF, 614 KB

english, 2011

35

Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans

Walker, Celia G., Browning, Lucy M., Mander, Adrian P., Madden, Jackie, West, Annette L., Calder, Philip C., Jebb, Susan A.

Journal:

British Journal Of Nutrition

Year:

2014

Language:

english

File:

PDF, 250 KB

english, 2014

36

Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes

Wason, James M. S., Mander, Adrian P.

Journal:

Journal of Biopharmaceutical Statistics

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

37

A Bayesian adaptive design for biomarker trials with linked treatments

Wason, James M S, Abraham, Jean E, Baird, Richard D, Gournaris, Ioannis, Vallier, Anne-Laure, Brenton, James D, Earl, Helena M, Mander, Adrian P

Journal:

British Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 674 KB

english, 2015

38

A product of independent beta probabilities dose escalation design for dual-agent phase I trials

Mander, Adrian P., Sweeting, Michael J.

Journal:

Statistics in Medicine

Year:

2015

Language:

english

File:

PDF, 685 KB

english, 2015

39

Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration

Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P., Lee, Shing M., Cheung, Ying Kuen K.

Journal:

Statistics in Medicine

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

40

Assessment of cognitive safety in clinical drug development

Roiser, Jonathan P., Nathan, Pradeep J., Mander, Adrian P., Adusei, Gabriel, Zavitz, Kenton H., Blackwell, Andrew D.

Journal:

Drug Discovery Today

Year:

2016

Language:

english

File:

PDF, 738 KB

english, 2016

41

Induction of ovulation with subcutaneous pulsatile gonadotropin-releasing hormone: correlation with body weight and other parameters

Thomas, Adrian K., Mander, Julie, Hale, Juliet, Walstab, Janet, Forrest, Michael S.

Journal:

Fertility and Sterility

Year:

1989

Language:

english

File:

PDF, 671 KB

english, 1989

42

An optimal stratified Simon two-stage design

Parashar, Deepak, Bowden, Jack, Starr, Colin, Wernisch, Lorenz, Mander, Adrian

Journal:

Pharmaceutical Statistics

Year:

2016

Language:

english

File:

PDF, 490 KB

english, 2016

43

Do single-arm trials have a role in drug development plans incorporating randomised trials?

Grayling, Michael J., Mander, Adrian P.

Journal:

Pharmaceutical Statistics

Year:

2016

Language:

english

File:

PDF, 975 KB

english, 2016

44

An adaptive design for updating the threshold value of a continuous biomarker

Spencer, Amy V., Harbron, Chris, Mander, Adrian, Wason, James, Peers, Ian

Journal:

Statistics in Medicine

Year:

2016

Language:

english

File:

PDF, 668 KB

english, 2016

45

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

Truman, Lucy A, Pekalski, Marcin L, Kareclas, Paula, Evangelou, Marina, Walker, Neil M, Howlett, James, Mander, Adrian P, Kennet, Jane, Wicker, Linda S, Bond, Simon, Todd, John A, Waldron-Lynch, Frank

Journal:

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

46

Improving outcomes in adults with epilepsy and intellectual disability (EpAID) using a nurse-led intervention: study protocol for a cluster randomised controlled trial

Ring, Howard, Gilbert, Nakita, Hook, Roxanne, Platt, Adam, Smith, Christopher, Irvine, Fiona, Donaldson, Cam, Jones, Elizabeth, Kelly, Joanna, Mander, Adrian, Murphy, Caroline, Pennington, Mark, Pulle

Journal:

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

47

Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial

Ahern, Amy L, Wheeler, Graham M, Aveyard, Paul, Boyland, Emma J, Halford, Jason C G, Mander, Adrian P, Woolston, Jennifer, Thomson, Ann M, Tsiountsioura, Melina, Cole, Darren, Mead, Bethan R, Irvine,

Journal:

Year:

2017

Language:

english

File:

PDF, 868 KB

english, 2017

48

Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials

Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P.

Journal:

Statistics in Medicine

Year:

2017

Language:

english

File:

PDF, 1.19 MB

english, 2017

49

Group sequential designs for stepped-wedge cluster randomised trials

Grayling, Michael J, Wason, James MS, Mander, Adrian P

Journal:

Clinical Trials

Year:

2017

Language:

english

File:

PDF, 755 KB

english, 2017

50

Application of Bayesian analysis to the doubly labelled water method for total energy expenditure in humans

Ruan, Yue, Bluck, Les C.J., Smith, James, Mander, Adrian, Singh, Priya, Venables, Michelle

Journal:

Rapid Communications in Mass Spectrometry

Year:

2018

Language:

english

File:

PDF, 843 KB

english, 2018